Frizzell, PhD, Norma

Associate Professor

Our laboratory is interested in a recently discovered post-translational modification of proteins known as S-(2-succino)cysteine (2SC), also termed protein succination. Protein succination occurs when fumarate (from the Krebs cycle) reacts with cysteines to form the irreversible modification 2SC. While we have studied this modification extensively in the adipocyte during diabetes, we are also interested in other conditions which lead to increased fumarate.

Biographical Profile

College
School of Medicine
Department
Pharm., Physiology & Neuroscience
Tenure Status
Tenured

International Activity

International Activities
Yes
Type of Activity
Research
Countries
UK, Australia, Japan
Description
Research on chemical modification of protein
Institutional Focus Areas
Biomedical Sciences
Extended Residence in Foreign Country
Yes (Ireland, United Kingdom)
Speaks Non-English Language
Yes (Irish, French)

Interest Background

Do you include students in your research?
Undergraduates and Graduates
Institutional Focus Areas
Biomedical Sciences
Personal Focus Areas
Diabetes, Mitochondrial Diseases

Recognition Awards, Honors, & Fellowships

Dates Type Description Foundation/Entity
2010 Award Junior Faculty Award American Diabetes Association
2012 Award Outstanding Undergraduate Research Mentor Award University of South Carolina
2017 Award Breakthrough Star Award Office of the Vice President for Research, University of South Carolina
2020 Award Distinguished Research Service Award University of South Carolina
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